Adverse Drug Reactions with First-Line and Second-Line Drugs in Treatment of Tuberculosis

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First– and Second–Line Drugs and Drug Resistance

Tuberculosis (TB) is caused by infection with Mycobacterium tuberculosis, which is transmitted through inhalation of aerosolized droplets. TB mainly attacks the lungs, but can also affect other parts of the body. TB is highly contagious during the active stage of the disease and can infect an individual through inhalation of as few as 10 Mycobacterium tuberculosis (MTB) bacteria. After inhalati...

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Adverse Events to First Line Anti-tuberculosis Drugs in Patients Co-infected with Hiv and Tuberculosis

BACKGROUND The combination and use of multiple drugs in the treatment of tuberculosis (TB) predispose to adverse drug events and reactions. This study evaluated the incidence, frequency, and severity of adverse events to first line anti-tuberculosis (anti-TB) drugs in patients with TB and co-infections with Human Immunodeficiency Virus (HIV). OBJECTIVE The objective of this study was to deter...

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Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 1: first-line drugs.

The main objectives of tuberculosis therapy are to cure the patients and to minimize the possibility of transmission of the bacillus to healthy subjects. Adverse effects of antituberculosis drugs or drug interactions (among antituberculosis drugs or between antituberculosis drugs and other drugs) can make it necessary to modify or discontinue treatment. We briefly review the new guidelines for ...

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Association of drug susceptibility testing results for first- and second-line drugs with treatment outcomes in patients with multidrug-resistant and extensively drug-resistant tuberculosis.

TO THE EDITOR—We read the metaanalysis by Bastos et al recently published in Clinical Infectious Diseases [1]. Because of our interest in the association of drug susceptibility testing (DST) results for firstand second-line drugs with treatment outcomes in patients with multidrugresistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis, we carefully read the entire article....

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ژورنال

عنوان ژورنال: Annals of the National Academy of Medical Sciences (India)

سال: 2021

ISSN: 0379-038X,2454-5635

DOI: 10.1055/s-0040-1722535